Asthma Patients with Fixed Bronchial Obstruction
نویسندگان
چکیده
منابع مشابه
Pulmonary Artery Agenesis with Bronchial Asthma
Unilateral Pulmonary Artery Agenesis (UPAA) is a rare congenital anomaly during the 4 th week of gestational age. It is defined as an absence of pulmonary parenchyma and its supporting artery. A 9-year-old girl was admitted to our hospital because of chronic cough. Chest examination showed a decrement in lung sound of right hemi-thorax with expiratory wheeze. Chest radiography (CXR) revealed a...
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In severe asthma, bronchodilator- and steroid-insensitive airflow obstruction develops through unknown mechanisms characterized by increased lung airway smooth muscle (ASM) mass and stiffness. We explored the role of a Regulator of G-protein Signaling protein (RGS4) in the ASM hyperplasia and reduced contractile capacity characteristic of advanced asthma. Using immunocytochemical staining, ASM ...
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Respiratory disturbances during sleep are recognized as extremely common disorders with important clinical consequences. Breathing disorders during sleep can result in broad range of clinical manifestations, the most prevalent of which are unrefreshing sleep, daytime sleepiness and fatigue, and cognitive impairmant. There is also evidence that respiratory-related sleep disturbances can contribu...
متن کاملFixed airways obstruction among patients with severe asthma: findings from the Singapore General Hospital-Severe Asthma Phenotype Study
BACKGROUND A subset of severe asthma patients has fixed airways obstruction, which is characterized by incomplete reversibility to bronchodilator challenge. We aimed to elucidate the factors associated with fixed airways obstruction in a cohort of patients with severe asthma in Singapore. METHODS 245 patients from the Singapore General Hospital-Severe Asthma Phenotype Study (SGH-SAPS) were sc...
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Background: Asthma is recognized as a common cause of disability, of great economic cost, and of preventable deaths. In this study we aimed to test our hypothesis to evaluate the relationship between the Human Platelet Antigen-1(HPA-1) polymorphism and bronchial asthma and its severity, which would suggest genetic variances that may be responsible for expression or activation of these receptors...
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ژورنال
عنوان ژورنال: Respiration
سال: 2012
ISSN: 1423-0356,0025-7931
DOI: 10.1159/000332828